Alubra : Hydrophilic lubricant
It is composed of Sodium Stearyl Fumarat.
Salt of stearic acid is most popular worl wide as lubricant (eg. Mg Stearate) but major problem for lubrication by such stearate is retardation of dissolution due to coating of particles and repels water and avoid wetting.
Fumarate group is added in stearat salt which increase hydrophilicity so dissolution problem will be avoided.
Avicel DG: Dry granulation grade Microcrystalline cellulose
Composed of Dicalcium phosphate and MCC used for roller compaction and dry granulation.
DCP is brittle in nature and MCC is compressible. So Breaking of Brittle DCP increase surface area and lids to Re-compression.
No comments:
Post a Comment